We love science so you can rest assured that if we have included it in our formulation, there is evidence to support efficacy of the ingredient.
Here is a selection of research that has informed the development of Cacao Latte:
1. Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable bowel syndrome induced by the prolonged addition of soluble fibers to usual drug therapy.
Watanabe H, Inoue T, Miyamoto L, Ono Y, Matsumoto K, Takeda
M, Tsuchiya K.
J Med Invest. 2024;71(1.2):121-128. doi: 10.2152/jmi.71.121.
PMID: 38735707
2. Bacterial, short-chain fatty acid and gas profiles of partially hydrolyzed guar gum in vitro fermentation by human fecal microbiota.
Pi XE, Fu H, Yang XX, Yu ZC, Teng WL, Zhang Y, Ye XW, Quan
HH, Lu LZ, Liu W.
Food Chem. 2024 Jan 1;430:137006. doi:
10.1016/j.foodchem.2023.137006. Epub 2023 Jul 27.
PMID: 37541036
3. Effects of partially hydrolyzed guar gums of different molecular weights on a human intestinal in vitro fermentation model.
Sasaki D, Sasaki K, Abe A, Ozeki M, Kondo A.
J Biosci Bioeng. 2023 Jul;136(1):67-73. doi:
10.1016/j.jbiosc.2023.04.002. Epub 2023 Apr 26.
PMID: 37105857
4. Randomized Controlled Trial on the Effect of Partially Hydrolyzed Guar Gum Supplementation
on Diarrhea Frequency and Gut Microbiome Count Among Pelvic Radiation Patients.
Rosli D, Shahar S, Manaf ZA, Lau HJ, Yusof NYM, Haron MR,
Majid HA.
JPEN J Parenter Enteral Nutr. 2021 Feb;45(2):277-286. doi:
10.1002/jpen.1987. Epub 2020 Sep 10.
PMID: 32740950 Clinical Trial.
5. Prebiotic Effects of Partially Hydrolyzed Guar Gum on the Composition and Function of the
Human Microbiota-Results from the PAGODA Trial.
Reider SJ, Moosmang S, Tragust J, Trgovec-Greif L, Tragust
S, Perschy L, Przysiecki N, Sturm S, Tilg H, Stuppner H, Rattei T, Moschen AR.
Nutrients. 2020 Apr 28;12(5):1257. doi: 10.3390/nu12051257.
PMID: 32354152 . Clinical Trial.
6. Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A,
Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R.
J Pediatr Surg. 2019 Dec;54(12):2514-2519. doi:
10.1016/j.jpedsurg.2019.08.048. Epub 2019 Sep 2.
PMID: 31515113
7. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics
and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and
Parallel-Group Clinical Trial.
Yasukawa Z, Inoue R, Ozeki M, Okubo T, Takagi T, Honda A,
Naito Y.
Nutrients. 2019 Sep 10;11(9):2170. doi: 10.3390/nu11092170.
PMID: 31509971 . Clinical Trial.
8. Study on the ability of partially hydrolyzed guar gum to modulate the gut microbiota and
relieve constipation.
Fu X, Li R, Zhang T, Li M, Mou H.
J Food Biochem. 2019 Feb;43(2):e12715. doi:
10.1111/jfbc.12715. Epub 2018 Nov 14.
PMID: 31353659
9. Dietary supplementation with partially hydrolyzed guar gum helps improve constipation
and gut dysbiosis symptoms and behavioral irritability in children with autism
spectrum disorder.
Inoue R, Sakaue Y, Kawada Y, Tamaki R, Yasukawa Z, Ozeki M,
Ueba S, Sawai C, Nonomura K, Tsukahara T, Naito Y.
J Clin Biochem Nutr. 2019 May;64(3):217-223. doi:
10.3164/jcbn.18-105. Epub 2019 Mar 7.
PMID: 31138955 .
10. In vitro analysis of partially hydrolyzed guar gum fermentation on identified gut
microbiota.
Carlson J, Gould T, Slavin J.
Anaerobe. 2016 Dec;42:60-66. doi:
10.1016/j.anaerobe.2016.08.006. Epub 2016 Aug 30.
PMID: 27585552
11. Role of PHGG as a dietary fiber: a review article.
Quartarone G.
Minerva Gastroenterol Dietol. 2013 Dec;59(4):329-40.
PMID: 24212352 Review.
12. Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a
randomized clinical trial in constipated women.
Linetzky Waitzberg D, Alves Pereira CC, Logullo L, Manzoni
Jacintho T, Almeida D, Teixeira da Silva ML, Matos de Miranda Torrinhas RS.
Nutr Hosp. 2012 Jan-Feb;27(1):123-9. doi:
10.1590/S0212-16112012000100014.
PMID: 22566311 Clinical Trial.
13. Characterizing
the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study.
Komiya S, Naito Y, Okada H, Matsuo Y, Hirota K, Takagi T,
Mizushima K, Inoue R, Abe A, Morimoto Y.
J Clin Biochem Nutr. 2020 Jul;67(1):105-111. doi:
10.3164/jcbn.20-53. Epub 2020 Jun 5.
PMID: 32801476 .
14. Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial
changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha L, Kim S, Lee S, Chae S, Chun WY, Shin
DM.
J Nutr Biochem. 2022 Jan;99:108854. doi:
10.1016/j.jnutbio.2021.108854. Epub 2021 Sep 14.
PMID: 34530112 Clinical Trial.
15. Benefits of Polyphenols and Methylxanthines from Cocoa Beans on Dietary Metabolic
Disorders.
Jean-Marie E, Bereau D, Robinson JC.
Foods. 2021 Aug 31;10(9):2049. doi: 10.3390/foods10092049.
PMID: 34574159 . Review.
16. Interactions
between polyphenols from Theobroma cacao and Lactobacillales to evaluate the potential of a combined strategy for intestinal free-fatty acid removal.
Quiroz-Eraso S, Rodríguez-Castaño GP, Acosta-González A.
Curr Res Food Sci. 2023 Sep 23;7:100594. doi:
10.1016/j.crfs.2023.100594. eCollection 2023.
PMID: 37790859 .
17. Bioavailability
and metabolism of selected cocoa bioactive compounds: A comprehensive review.
Oracz J, Nebesny E, Zyzelewicz D, Budryn G, Luzak B.
Crit Rev Food Sci Nutr. 2020;60(12):1947-1985. doi:
10.1080/10408398.2019.1619160. Epub 2019 May 24.
PMID: 31124371 Review.
18. Metabolomics
view on gut microbiome modulation by polyphenol-rich foods.
Moco S, Martin FP, Rezzi S.
J Proteome Res. 2012 Oct 5;11(10):4781-90. doi:
10.1021/pr300581s. Epub 2012 Sep 6.
PMID: 22905879 Review.
19. Mechanisms
by which cocoa flavanols improve metabolic syndrome and related disorders.
Strat KM, Rowley TJ 4th, Smithson AT, Tessem JS, Hulver MW,
Liu D, Davy BM, Davy KP, Neilson AP.
J Nutr Biochem. 2016 Sep;35:1-21. doi:
10.1016/j.jnutbio.2015.12.008. Epub 2016 Jan 23.
PMID: 27560446 Review.
20. Regular Consumption of Cocoa and Red Berries as a Strategy to Improve Cardiovascular
Biomarkers via Modulation of Microbiota Metabolism in Healthy Aging Adults.
García-Cordero J, Martinez A, Blanco-Valverde C, Pino A,
Puertas-Martín V, San Román R, de Pascual-Teresa S.
Nutrients. 2023 May 13;15(10):2299. doi: 10.3390/nu15102299.
PMID: 37242181 .
21. Cocoa seeds
and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA
amplicon sequencing.
Farag MA, Hariri MLM, Ehab A, Homsi MN, Zhao C, von Bergen
M.
Crit Rev Food Sci Nutr. 2024;64(10):3122-3138. doi:
10.1080/10408398.2022.2130159. Epub 2022 Oct 3.
PMID: 36190306 Review.
22. Probiotic
modulation of gut microbiota by Bacillus coagulans MTCC 5856 in healthy subjects: A randomized, double-blind, placebo-control study.
Majeed M, Nagabhushanam K, Mundkur L, Paulose S, Divakar H,
Rao S, Arumugam S.
Medicine (Baltimore). 2023 May 19;102(20):e33751. doi:
10.1097/MD.0000000000033751.
PMID: 37335737 . Clinical Trial.
23. The effects
of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A
randomized, double-blind, placebo-controlled study.
Majeed M, Nagabhushanam K, Paulose S, Arumugam S, Mundkur L.
Medicine (Baltimore). 2023 Mar 3;102(9):e33109. doi:
10.1097/MD.0000000000033109.
PMID: 36862903 . Clinical Trial.
24. Comparative
evaluation for thermostability and gastrointestinal survival of probiotic Bacillus coagulans MTCC 5856.
Majeed M, Majeed S, Arumugam S, Ali F, Beede K.
Biosci Biotechnol Biochem. 2021 Mar 24;85(4):962-971. doi:
10.1093/bbb/zbaa116.
PMID: 33580694
25. Evaluation
of probiotic Bacillus coagulans MTCC 5856 viability after tea and coffee
brewing and its growth in GIT hostile environment.
Majeed M, Majeed S, Nagabhushanam K, Arumugam S, Beede K,
Ali F.
Food Res Int. 2019 Jul;121:497-505. doi:
10.1016/j.foodres.2018.12.003. Epub 2018 Dec 4.
PMID: 31108774
26. Bacilluscoagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot
clinical study.
Majeed M, Nagabhushanam K, Arumugam S, Majeed S, Ali F.
Food Nutr Res. 2018 Jul 4;62. doi: 10.29219/fnr.v62.1218.
eCollection 2018.
PMID: 29997457 .
27. Nondigestible
carbohydrates, butyrate, and butyrate-producing bacteria.
Fu X, Liu Z, Zhu C, Mou H, Kong Q.
Crit Rev Food Sci Nutr. 2019;59(sup1):S130-S152. doi:
10.1080/10408398.2018.1542587. Epub 2018 Dec 22.
PMID: 30580556 Review.
28. Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review.
Yang Q, Liang Q, Balakrishnan B, Belobrajdic DP, Feng QJ,
Zhang W.
Nutrients. 2020 Jan 31;12(2):381. doi: 10.3390/nu12020381.
PMID: 32023943 . Review.
29. The human-microbiome superorganism and its modulation to restore health.
Salvucci E.
Int J Food Sci Nutr. 2019 Nov;70(7):781-795. doi:
10.1080/09637486.2019.1580682. Epub 2019 Mar 7.
PMID: 30843443 Review.
30. Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran
Arabinoxylan Compound.
Schupfer E, Ooi SL, Jeffries TC, Wang S, Micalos PS, Pak SC.
Molecules. 2023 Jul 14;28(14):5400. doi:
10.3390/molecules28145400.
PMID: 37513272 .
31. The Effect of Hydrolyzed and Fermented Arabinoxylan-Oligo Saccharides (AXOS) Intake on the Middle-Term Gut Microbiome Modulation and Its Metabolic Answer.
Polo A, Albiac MA, Da Ros A, Ardèvol VN, Nikoloudaki O,
Verté F, Di Cagno R, Gobbetti M.
Nutrients. 2023 Jan 23;15(3):590. doi: 10.3390/nu15030590.
PMID: 36771297 .
32. A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans.
Benítez-Páez A, Kjølbæk L, Gómez Del Pulgar EM, Brahe LK,
Astrup A, Matysik S, Schött HF, Krautbauer S, Liebisch G, Boberska J, Claus S,
Rampelli S, Brigidi P, Larsen LH, Sanz Y.
mSystems. 2019 May 28;4(4):e00209-19. doi:
10.1128/mSystems.00209-19.
PMID: 31138673 .
33. Arabinoxylans
as Functional Food Ingredients: A Review.
Zannini E, Bravo Núñez Á, Sahin AW, Arendt EK.
Foods. 2022 Apr 1;11(7):1026. doi: 10.3390/foods11071026.
PMID: 35407113 . Review.